I noticed, however, that I get an appreciable amount of digital noise when using the USB cable.
My signal path is as follows:
Miniatur via USB to an iMac i7 (running 10.6.

iMac to MOTU 828 Mk3 (latest drivers) connected via USB (no other USB peripherals connected)
Minitaur audio out to MOTU input using a Van Damme instrument cable.
MOTU, iMac and Minitaur are all on the same power strip (to avoid ground loops).
Any suggestions appreciated.
Richard