I've taken my Little Phatty Tribute (for CV out mod and RAM upgrade) and my Voyager Old School (for other modes and calibration) separately to Asheville, once on a drive over from Raleigh during a business trip and the other time on the way driving to Florida with family. But in both cases, I had Moog ship it back to me.
No issues but I'm not saying that you won't have issues because you never know.
If it's your baby, take the drive, especially if you've never been to Asheville, leave at 6am; get there around the time they open, check out the demo room, schedule a factory tour through Jason, have some lunch in Asheville and head back by evening. Well worth the day investment to check the place out. If you coordinate it ahead of time, maybe they can slot you in to do the work while you hang around the area? I can't see it taking more than a few hours to resolve but I'm guessing.
'76 Minimoog, Moog Voyager Select, Taurus 3, Opus 3; Oberheim Son of 2-voice+2; Sequential ProOne; Juno 106; 48 of MU Modular; Kurzweil 250; Hammond M3; Fender '75 Jazz, G'shop Precision, Tony Franklin Fretless, Hoppus, Roadworn 60's Jazz; MF101,104M,105M